More brain activity is not always better when it comes to memory, attention
The review has just been published in a special 'Pharmacology of Cognition' issue of the British Journal of Pharmacology . In the paper, Tobias Bast, Stephanie McGarrity and Marie Pezze from the School of Psychology at The University of Nottingham highlight recent evidence, which suggests that too much uncontrolled activity in specific brain areas may lead to the cognitive impairments characterizing these conditions. Neurons in the brain interact by sending each other chemical messages, so-called neurotransmitters. Gamma-aminobutyric acid (GABA) is the most common inhibitory neurotransmitter, which is important to restrain neural activity, preventing neurons from getting too trigger-happy and from firing too much or responding to irrelevant stimuli. In the extreme, impaired inhibitory GABA transmission can cause epileptic seizures. In addition, as highlighted in the review, more subtle impairments in inhibitory GABA transmission, which are below the threshold to cause seiz...